Low-binding Surface Technology
Sorenson BioScience offers most of their pipette tips with low binding surface technology. A calibrated pipettor may be 99% accurate and precise, but tips can compromise such accuracy and precision by binding sample. Low binding tips improve accuracy and precision by utilizing bonded polymer technology. The proprietary polymer is bonded to the tip to create a hydrophobic surface that reduces the surface tension of the interior wall of the pipette tip and minimizes the bonding of DNA and protein molecules to the tip material. No additives such as silicone are used; consequently, no leaching or sample degradation occur. The chemically resistant polymer is completely inert and is not affected by common laboratory solvents such as chloroform, chloroethane, or acetone. All products are certified Nuclease free, non-pyrogenic, and Human DNA/PCR Inhibitor-free.
Low Binding Surface Technology Applications
- Pipetting long, sticky molecules such as DNA, proteins, or peptides, which tend to bind to the tip surfaces.
- Quantitative assays in which sample binding can significantly alter results
- Critical, small volume protocols that require a high degree of accuracy. At these ultramicro volumes, minute amounts of retained sample represent a large percentage of the total sample volume.
- Replace siliconized tips. Silicone will leach into samples and can degrade DNA. Siliconized tips are also less effective after autoclaving.
- Pipetting expensive reagents. Minimize the amount of liquid lost to wetting the tip.
Conventional Tip
Low-binding Tip
Sorenson commissioned independent studies to validate the claims of performance. Read the reports here.
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